Chinese scientists have achieved significant results by applying the theory of Qi and collaterals to guide anti-aging research.

　　On March 27, a press conference on the construction of a theoretical system for collateral disease and its transformation and application results was held in Beijing, sponsored by the World Federation of Chinese Medicine Societies Professional Committee on Collateral Diseases and the World Federation of Chinese Medicine Societies Anti-Aging Professional Committee. At the meeting, Academician Wu Yiling gave a report titled “Construction of the Theoretical System of Collateral Disease and Its Transformation and Application”, detailing the series of scientific research results achieved by his systematically constructed Qi-Collateral Theory and the Jing-Qi-Shen Theory to guide anti-aging research.

Academician Wu Yiling gave a report titled “Construction of the Theoretical System of Collateral Disease and Its Transformation and Application”.

　　For the first time, the Qi-luo theory and Jing-Qi-Shen theory were established to guide anti-aging research.

　　Academician Wu Yiling pointed out in the report that the scientific research team led by himAfter more than 40 years of unremitting efforts, based on the inheritance of ancient research on collateral diseases, he systematically constructed a theoretical system of collateral diseases for the first time, created a new discipline of collateral diseases in traditional Chinese medicine, and established two major branches of the discipline – “Pulse Theory” and “Qi Lu Theory”, which are recognized by traditional Chinese medicine. Master Lu Zhizheng evaluated it as “the fourth milestone in the history of research on collateral diseases in traditional Chinese medicine”. Among them, for the first time, it was guided by the theory of qi and collaterals, essence, qi and spirit, and made major breakthroughs in anti-aging theory, clinical practice, experiments and new drugs.

　　Academician Wu Yiling introduced that the theory of essence, qi, and spirit constructed based on the theory of qi and collaterals summarizedThe holistic view of life that “Jing is the origin of life, Qi is the driving force of life, and God is the embodiment of life” explains key scientific issues such as the formation of life, the driving force of life operation, the functions of organs, and spiritual thinking, and proposes the core pathogenesis of aging—— Deficiency of kidney essence is the root of aging, deficiency of vitality is the key to aging, and depletion of body and mind is the manifestation of aging. It is emphasized that the longevity of life depends on the prosperity and decline of essence, energy, and spirit. Deficiency of essence and vitality affects the five internal organs because deficiency of kidney essence and vitality leads to systemic aging. The common pathogenesis of and related diseases has established the treatment method of tonifying the kidneys and replenishing essence, warming and supporting vitality, and replenishing the body and mind.

　　“Research on the Anti-aging Evaluation Technology and Integration Mechanism of Traditional Chinese Medicine Guided by the Theory of Essence, Qi, and Spirit of Qiluo Theory” was approved as a key project of the National Key R&D Program “Modernization of Traditional Chinese Medicine”

　　At the meeting, Academician Wu Yiling introduced the national key R&D plan projects announced by the Ministry of Science and Technology“Modernization of Traditional Chinese Medicine” Key Project“Research on the anti-aging evaluation technology and integration mechanism of traditional Chinese medicine guided by the theory of Qiluo theory, essence, Qi and spirit”.

　　This project is guided by the theory of Qi and Luo, Jing Qi and Shen, to build a multi-modal model and a multi-level evaluation index system, determine the optimal time and space window for intervention, and reveal the biological basis of the core pathogenesis of aging; explore the methods of nourishing the kidneys and replenishing the kidneys in multiple systems, tissues, and organs. The anti-aging biological mechanism of essence prescriptions has clarified the material basis and key targets of the drug efficacy; elucidated the differentiated characteristics of tissues and organs of the aging mechanism, and interacted with known risk factors to cause geriatric diseases, opening up new and effective anti-aging ways to prevent and treat geriatric diseases.

　　For the first time, innovative traditional Chinese medicine for tonifying kidney essence and anti-aging was developed based on eight seed medicines, explaining the power of seeds.

　　“Ben Cao Zheng” has“Everything is solid, nourishes the yin of the five internal organs and replenishes the essence and qi, and everything is heavy, replenishing the kidneys and strengthening the kidney qi”.Academician Wu Yiling led a scientific research team to develop the Bazi Kidney Capsule under the guidance of the theory of Qi and Luo theory, Jing Qi Shen theory.absorbing the essence of kidney-tonifying medicines from past dynasties,Take dodder, wolfberry, schisandra, cnidium, golden cherry, raspberry, leek, toochean root, etc.8 kinds of seed medicine nourish and replenish kidney essence. This recipe also draws on the deer antler used by Ye TianshiwaitThe experience of nourishing the kidneys and replenishing essence with flesh-and-blood products makes the effects of nourishing kidney essence complement each other, supplemented bybornRehmannia glutinosa nourishes kidney yin,Epimedium, Morinda officinalis and Cistanche deserticola warm and support kidney yang,It is also combined with ginseng to warm and support vitality. All medicines are used together, and the medicine is specifically designed to nourish the kidneys and essence, regulate yin and yang, warm and support the vitality, enhance the body’s vitality, improve vitality, and delay aging. It is an innovative traditional Chinese medicine that tonifies the kidneys and resists aging.

　　Cuscuta has the effects of nourishing the kidneys and essence, nourishing the liver and improving eyesight; wolfberry nourishes the kidneys and resists aging, and is one of the top ten traditional anti-aging Chinese medicines; Schisandra chinensis has the effects of nourishing qi, strengthening yin, and replenishing essence; raspberries warm the body and tonify deficiency; cnidium monnieri It has the effect of warming the kidneys and aphrodisiac; Melanium japonica has the effects of clearing away heat and promoting qi; Golden cherry seeds are a famous medicine that can only nourish the kidneys and strengthen essence; leek seeds have the effect of warming the kidneys and aphrodisiac.

　　The whole formula draws on the essence of two thousand years of experience in kidney-tonifying medicine. It has the anti-aging effects of nourishing essence and transforming qi, nourishing qi and transforming spirit, and replenishing body and soul. It fundamentally nourishes kidney essence and resists aging.

　　Research has confirmed that Bazi Bushen Capsule can regulate eight major mechanisms that interfere with human aging.

　　The latest anti-aging research published in authoritative international medical magazines such as “Nature” and “Senescent Cell” shows that human aging has biological consequences.12 major mechanisms, through therapeutic intervention in these mechanisms, aging can be slowed down, stopped or even reversed.Research shows that the innovative Chinese medicine Bazi Bushen Capsule can regulate eight of these mechanisms.

　　Academician Wu Yiling pointed out that anti-aging research related to Bazi Bushen Capsule has confirmed that the drug can“Reducing senescent cells” “Maintaining mitochondrial homeostasis” “Regulating epigenetics” “Maintaining stem cell vitality”“Improving intercellular communication”Reduce telomere loss““Inhibit inflammatory response” “Improve intestinal microecology”biological leveleightlarge mechanism to delay aging and prevent and treat aging-related diseases.

　　Physiological age and genome of different human tissues and cell typesThe degree of DNA methylation is highly correlated with,A publication in International MedicineA study in the SCI journal “Biomedicine and Drug Therapy” titled “Bazi nourishes the kidneys to delay epigenetic aging and extend the healthy lifespan of naturally aging mice”,Revealed for the first time that Bazi Bushen Capsule reversesThe mechanism of DNA methylation aging and delaying overall aging.The study showed that the subjects were of chronological age52-week-old mice (approximately equivalent to 44 years old in humans) were given Bazi Bushen Capsules for 11 weeks.,The chronological age of mice is63 weeks old (approximately equivalent to 50 years old in humans), but its methylation age was reversed to approximately 37 weeks old (approximately equivalent to 35 years old in humans).

　　Eight seeds nourishing the kidneys can significantly reduce the mortality of stress-aging animals

　　In life, it is not difficult for us to find that the greater the pressure a person has, the faster he ages.In fact, the behavioral and psychological characteristics of mice are also similar and comparable to humans. Researchers have11-month-old mice (approximately equivalent to 38 years old in humans) were randomly subjected to 12 types of chronic mild stress, simulating the premature aging of humans caused by factors such as staying up late, poor lifestyle, and physical and mental stress. One year later, the mice reached 23 months of age, which is equivalent to 79 years in humans. It was observed that the mortality rate of mice in the stress-aging group was 72%, which was 6 times that of the natural aging group. The mortality rate of mice taking Bazi tonify the kidney was only 72%. 28%, effectively reducing the mortality rate by 44%, and the eight subgroups of mice that are still alive are in good mental activity, with shiny black and thick coats, and their survival status is significantly better than that of the stress-aging group.The results show: BaziReplenishing the kidneys can significantly improve premature aging caused by stress, improve living conditions, and extend healthy lifespan.

　　The latest research results confirm that Bazi nourishes the kidneys and prolongs the life span of naturally aging mammals.6 months

　　Academician Wu Yiling introduced a latest scientific research result in his report. Researchers at the Anti-Aging Center of the National Key Laboratory of Collateral Disease Theory Innovation and Transformation led by him conducted the first domestic animal full life cycle recording.Large-scale anti-aging study of 1,200 mice.As ofat presentmice fed with Bazi Bushen Capsule high-dose group and low-dose group had the longest life span.ExceedGot it36 months, while all mice in the natural aging group died at 30 months of age, and all mice in the NMN group died at 32 months of age. The longest life span of the mice in the Bazi kidney-tonifying group was 6 months longer than the naturally aging mice and 4 months longer than the NMN group, significantly improving the life span and health status of the mice. The surviving mice in the high- and low-dose Bazi kidney-tonifying groups were in good condition, with normal diet and activities. Research is still ongoing,researcherContinue to observe how long Bazi tonifying the kidneys can extend the life of mice.According to literature reportsit is known that the life span of mice of the same strain is generally20 to 30 months. One month in mice is equivalent to 3.5 to 4 years in humans, which is an extension of 6 months.manyIt can be said that Bazi Bushen Capsule has challenged the length of life and achieved a major breakthrough.

　　Animal experiments are an important part of evaluating the efficacy and safety of drugs and provide important reference for clinical trials. The above-mentioned experimental research on Bazi Bushen Capsule is of immeasurable significance to the clinical application of traditional Chinese medicine in anti-aging.

　　Eight seeds tonify the kidneys can delay the aging of multiple systems and prevent and treat geriatric diseases.

　　《The 2017 Global Burden of Disease Study noted that 92 of 293 diseases were identified as age-related, the most common being heart disease, diabetes, COPD, stroke, Alzheimer’s disease, chronic kidney disease and cancer, accounting for about half of deaths are attributed to chronic aging-related diseases. Anti-aging and anti-aging research are of great significance to the Healthy China strategy.

　　Academician Wu Yiling introduced in his report that the anti-aging scientific research team led by him has established a variety of aging-related disease models to conduct in-depth research on the anti-aging effect of Bazi Bushen Capsule on the system. A series of experimental studies have confirmed that Bazi Bushen Capsule has systemic intervention and comprehensive anti-aging effects on the functional decline of multiple systems such as nerves, vision, skin, bones, muscles, circulation, breathing, digestion, immunity, and reproduction.

　　In terms of anti-aging of the nervous system:Scientific researchers useThree aging mouse models and dementia mouse models have confirmed that Bazi tonifying kidney can significantly improve cerebral blood flow and blood-brain barrier permeability, protect central nervous cells, shorten the time for mice to find targets, and improve mice’s learning ability and memory. Recognition ability, motor coordination ability and social ability indicate that Bazi tonifying kidney can significantly improve the aging of the nervous system.

　　In terms of anti-aging skin:Skin is one of the first tissues in the body to show signs of aging.In terms of improving skin aging, Professor Bian Yuhong of Tianjin University of Traditional Chinese Medicine has conducted a series of anti-skin aging experiments. The results confirmed that: Bazi tonifying kidney can reduce oxidative damage, reduce the number of senescent cells, improve skin renewal ability, maintain the amount of collagen, and improve skin. Structure of epidermis and dermis.

　　In terms of anti-aging of the motor system:For scientific researchersThree aging animal models have confirmed that Bazi tonifying kidney can significantly reduce bone loss and increase bone density and strength. Professor Zhang Dongwei of Beijing University of Chinese Medicine, Professor Bian Yuhong of Tianjin University of Chinese Medicine, and Professor Wang Dandong of Hebei Medical University have all conducted research on the effect of Bazi Bushen Capsule on improving osteoporosis in aging model animals.

　　After the age of 30, the body’s muscle content decreases by 1% to 2% every year with age, and by the age of 60 it is only equivalent to 50% of what it was when you were young. This is one of the important reasons for falls and fractures in the elderly. In natural aging experiments and sarcopenia models, it was found that Bazi tonifying kidney can significantly delay muscle aging, inhibit muscle atrophy, reduce fiber deposition, improve muscle endurance, grip, balance, and improve motor function.

　　In terms of anti-aging of the circulatory system:Atherosclerosis is known as an alarm or sign of vascular aging. In a model simulating atherosclerotic lesions after withdrawal of female hormones, Bazi Bushen can inhibit plaque formation and reduce plaque area by regulating hormones, blood lipid levels and other mechanisms. It is suggested that Bazi tonifying the kidney has certain preventive and therapeutic effects on atherosclerosis. Increased myocardial stiffness and reduced diastolic function caused by myocardial fibrosis and thickening of the ventricular wall are important manifestations of heart aging. In severe cases, it can affect the heart’s blood supply function to tissues and organs. Research results show that Bazi tonifying the kidney can significantly reduce myocardial fibrosis, delay the thickening of the heart ventricular wall, and improve cardiac diastolic function. The prolonged exercise time of mice also suggests the effect of Bazi tonifying the kidney on cardiac function.

　　In terms of anti-aging of the respiratory system:Pulmonary fibrosis is an important manifestation of lung aging, which can reduce lung elasticity and affect the respiratory function of the lungs. In the oxidative damage and silica dust-induced lung injury models, it was found that Bazi tonifying kidney significantly reduced oxidative damage in lung tissue, improved alveolar structure, reduced the number of senescent cells, and inhibited pulmonary fibrosis, suggesting that Bazi tonifying kidney can delay lung aging.

　　In terms of anti-aging of the digestive system:Intestinal flora is the aging clock in the intestine. Intestinal flora imbalance can destroy the intestinal barrier function, which is not only a manifestation of intestinal aging, but also promotes the aging process. Research shows that Bazi Kidney can regulate intestinal flora, increase probiotics, reduce harmful bacteria, reduce intestinal senescent cells, increase the number and length of intestinal villi, and improve intestinal barrier function.

　　In terms of anti-aging of the reproductive system:Decline in reproductive capacity is considered to be one of the main manifestations of aging. In studies on aging mouse models, it was found that Bazi tonifying kidney has a protective effect on gonad structure, functional integrity, and sperm quality and quantity, thereby maintaining male reproductive capacity.

　　Many of the above experiments can confirm that Bazi tonifying the kidneys can significantly delay the functional decline of multiple systems and prevent and treat the occurrence and development of aging-related diseases.

　　Clinical research on Bazi tonifying kidney and anti-aging has achieved significant results

　　Whether a drug is safe and effective depends on basic experiments, animal experiments, and more importantly, clinical research. Only when it is placed on humans can the clinical efficacy of the drug be tested. Led by Professor Xu Fengqin from Xiyuan Hospital, China Academy of Chinese Medical Sciences,The anti-aging randomized, double-blind, placebo-controlled, multi-center clinical study of Bazi Bushen Capsules jointly completed by 9 centers has achievedGot itMajor scientific research achievements.

　　Research was selected530 subjects were randomly divided into 2 groups. The experimental group took Bazi tonify the kidney, and the control group took a placebo without drug ingredients. The study found that Bazi tonifying the kidney can significantly improve the neuropsychiatric, skin, hair, skeletal muscles, Urogenital and other symptoms of premature aging improve the physical and mental debility, improve the quality of healthy life, and also enhance the exercise ability and endurance of the elderly. It also has a definite improvement effect on telomerase activity, an important sign of aging.

　　The fruitful results of this series of anti-aging research were organized by the World Federation of Chinese Medicine Societies.“The theory of Qi and Luo guides the anti-aging research of Bazi Bushen Capsule,” experts argue. “The preliminary research of this project established the theory of essence, Qi, and spirit based on the theory of Qi and Lu for the first time, forming a new idea for anti-aging research; the patented traditional Chinese medicine Bazi Bushen Capsule was developed. , has the anti-aging effects of tonifying the kidneys and replenishing essence, regulating yin and yang, warming and nourishing vitality, and replenishing the body and mind, and has become a representative Chinese patent medicine for anti-aging in traditional Chinese medicine. These studies combine the innovation of traditional Chinese medicine theory with modern science and technology, and in traditional Chinese medicine Significant progress has been made in anti-aging research and important original results have been produced, laying a solid foundation for future in-depth research.”

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