Academician Wu Yiling pioneered the venation theory, opening up the “venations” for the prevention and treatment of microvascular disease

　　Microvascular disease is a systemic disease and a difficult problem for the international medical community. It is an important factor in the occurrence and development of major diseases such as cardiovascular and cerebrovascular diseases and diabetes. It is also a key factor that currently makes it difficult to improve the clinical efficacy of these diseases.3moon27On the same day, at the conference on the construction of the theoretical system of collateral disease and its transformation and application results, Professor Wu Yiling, an academician of the Chinese Academy of Engineering, introduced a series of achievements in theory, mechanism, clinical and other aspects around the project of “Construction of the collateral theory of traditional Chinese medicine and its guidance for the prevention and treatment of microvascular disease” Results.

　　“The construction of the theory of collaterals in traditional Chinese medicine promotes the prevention and treatment of microvascular disease“The project was selected as the landmark scientific and technological achievement of traditional Chinese medicine in the new era.(2012–2022),Ranked first in category“The formation of new theories and disciplines of traditional Chinese medicine“first placethe project has wonFirst Prize of National Science and Technology Progress Award.

A press conference on the construction of the theoretical system of collateral disease and its transformation and application results was held in Beijing.

Academician Wu Yiling gave a report titled “Construction of the Theoretical System of Collateral Disease and Its Transformation and Application” at the meeting.

　　Choroid theory provides original theoretical guidance to solve the problem of microvascular disease

　　“Microcirculation” states that the essence of cardiovascular disease is microcirculation disorder, which is the main cause and aggravating factor of cardiovascular disease.“Revolving around an international problem such as microvascular disease, combined with major diseases such as heart, brain, and diabetes, major innovations have been made in the academic theory of traditional Chinese medicine.” Academician Wu Yiling pointed out that “mai” in traditional Chinese medicine is called blood vessels, which are the channels for running blood. It is anatomically identical to blood vessels in Western medicine. Veins are the branches of blood vessels, including capillaries and microcirculation.through two973The project has constructed a new theoretical theory – the Pulse Theory, to guide the prevention and treatment of cardiovascular and cerebrovascular diseases and diabetic vascular complications. It has proposed the core theory of the Pulse Theory – Yingwei Theory, established clinical syndrome differentiation and diagnosis standards for vascular lesions, and proposed Medication rules for regulating Yingwei Qi and blood to treat vascular lesions. Under the guidance of the choroid theory, Tongxinluo Capsules for the treatment of ischemic cardiovascular and cerebrovascular diseases, Shensong Yangxin Capsules for the treatment of arrhythmias, and Qili Qiangxin Capsules for the treatment of chronic heart failure were developed.nation973The expert group of the plan commented: “The theory of meridian theory and Yingwei theory has formed a new theory to guide the prevention and treatment of major microvascular diseases, and is an original achievement of academic research on traditional Chinese medicine.”

　　Protect microvascular endothelial cellsyesCore mechanisms for treating microvascular disease

　　Academician Wu Yiling pointed out:“Our more than ten research groups have2005Started research in 2016, right3.3Analysis of more than 10,000 pieces of research data reveals for the first time that microvascular disease is a complex network disease pattern with microvascular endothelial cell damage as the core and initiating factor, the participation of blood components and neurobody fluids, damage to the structure and function of organ tissue cell cells, and dynamic evolution of multi-dimensional space and time; The intervention of unblocking the collaterals normalizes the associated nodes of the complex network, and has more obvious advantages in protecting microvessels than the control group. “

　　Experiments have confirmed that unblocking collaterals to protect microvessels is a common mechanism for treating major clinical diseases of the heart, brain (glucose) and kidneys, and protecting microvascular endothelial cells is the core mechanism for solving the problem of microvascular disease. Because microvessels are protected, tissue blood perfusion in the microcirculation of the heart, brain, and kidneys is improved, thereby alleviating clinical conditions.nation973The plan acceptance expert group unanimously agreed: “This project has achieved a major breakthrough in the treatment of microvascular disease with traditional Chinese medicine.”

　　Evidence-based research confirms that dredging drugs can solve major clinical problems in cardiovascular and cerebrovascular diseases

　　Academician Wu Yiling said:“We have conducted a large number of evidence-based studies on three Chinese patent medicines that unblock collaterals to treat cardiovascular and cerebrovascular diseases – Tongxinluo Capsules, Shensong Yangxin Capsules, and Qili Qiangxin Capsules.” The results show that in the prevention and treatment of coronary heart disease,acute myocardial infarction,Arrhythmiachronic heart failureA series of achievements have been made in diseases such as acute myocardial infarction without reflow, premature ventricular insufficiency with cardiac insufficiency, sinus bradycardia with premature beats, chronic heart failure and other major international medical problems in the cardiovascular field.

　　Led by Professor Yang Yuejin,Nationwide124hospitals participatingRandomized, double-blind, placebo-controlledTongxinluo treatmentSTsegmental elevation typemyocardial infarction3797Clinical evidence-based study results show that Tongxinluo significantly reduces30Risk of adverse cardiovascular and cerebrovascular events36%reduce the risk of cardiovascular death30%; One year into the study, Tongxinluo continued to reduce the risk of adverse cardiovascular and cerebrovascular events36%reduce the risk of cardiovascular death27%,reduce1Annual risk of another myocardial infarction74%, providing effective therapeutic drugs to improve the long-term prognosis of acute myocardial infarction. The research paper was published in the Journal of the American Medical Association (Journal of the American Medical Association), one of the world’s four top medical journals.JAMA) published and received reviews2023The annual top ten academic advances in traditional Chinese medicine, the top ten medical researches in China, and the top ten highlights in the field of cardiovascular disease in China have become milestone breakthroughs in the internationalization of traditional Chinese medicine in the past century.

　　Previous studies have also shown that Tongxinluo has triple protective effects on blood, blood vessels, and ischemic tissues.“Tongxinluo Intervention in Carotid Artery Plaque”1212Clinical studies have shown that Tongxinluo can stabilize vulnerable plaques and reduce the incidence of “cardiovascular events”. “Tongxinluo Treats Ischemic Stroke”2007Clinical study results show that Tongxinluo can significantly improve the self-care ability and neurological function of patients with acute cerebral infarction.

　　Academician Wu Yiling introduced that the meridian theory guided the development of Shensong Yangxin Capsule for arrhythmia treatment. The outstanding features of this medicine are“Treat both fast and slow, and integrate adjustments.” A number of evidence-based medical studies on Shensong Yangxin Capsules have achieved good results.1476Clinical evidence-based medicine studies have confirmed that Shensong Yangxin is better than mexiletine in treating premature ventricular contractions; it is equally effective as propafenone in treating paroxysmal atrial fibrillation, and it increases ventricular rate on average in treating bradyarrhythmias.7.09Second-rate/point. “Shensong Yangxin Capsule for the treatment of premature ventricular contractions accompanied by cardiac insufficiency”“Evidence-based research shows that Shensong Yangxin can significantly improve cardiac function while reducing premature beats, providing a new therapeutic drug to solve this international clinical problem.” Shensong Yangxin Capsule treats sinus bradycardia with ventricular Evidence-based research on “premature ventricular contractions” shows that it can increase ventricular rate while reducing premature ventricular contractions, improve clinical symptoms, and fill the gap in drug treatment of “treating both fast and slow, integrating regulation”. “Shensong Yangxin Capsule is effective for920The results of a multicenter, randomized, double-blind, placebo-controlled clinical study on the prognostic impact of radiofrequency ablation in patients with atrial fibrillation showed that Shensong Yangxin Capsule reduced the1Atrial fibrillation recurrence rate within the year7.9%reduce the risk of recurrence40.4%this study is in2023After the release of the European Society of Cardiology Annual MeetingIt aroused strong response from the international medical community. Ge Junbo, an academician of the Chinese Academy of Sciences, commented:“Chinese research has made breakthrough progress in the field of atrial fibrillation treatment and provided solutions to the world’s treatment problems, which is a milestone.”

　　The choroid theory has guided the treatment of chronic heart failure and achieved a series of scientific research results.Led by Professor Li Xinli from the First Affiliated Hospital of Nanjing Medical University“Qili Qiangxin Capsule for the treatment of chronic heart failure512“Evidence-Based Study” confirms that adding Qili Qiangxin Capsule to standard drug treatment can significantly improve the clinical efficacy.16%.The results of this study were2013Published in the international authoritative magazine “Journal of the American College of Cardiology” (JACC), a review article “Make the Failing Heart Stronger” distributed by the editorial department——The Enlightenment of Traditional Chinese Medicine to Us” stated: “This promising research has opened the door to how to use the latest technology to study the synergistic effect of traditional Chinese medicine in the treatment of heart failure. This is a challenge, and we should do this. A big hug.” The study was also ratedJACCAcademic Highlights of the Year:“This study confirms the reliable efficacy of traditional Chinese medicine Qili Qiangxin Capsule, which can achieve synergistic effects with combined treatment with Western medicine, enabling patients with heart failure to achieve significant curative effects.”

　　2023At the annual meeting of the European Society of Cardiology, the results of the “Evaluation Study on Composite Endpoint Events of Qili Qiangxin Capsules in the Treatment of Chronic Heart Failure” were announced.This study adopted a randomized, double-blind, placebo-controlled, multi-center clinical research method to complete the efficacy of Qili Qiangxin on the composite endpoint of chronic heart failure.3119Example clinical evidence-based research.The results showed that Qili Qiangxin combined with standardized treatment reduced the risk of the primary composite endpoint of chronic heart failure compared with the control group.twenty two%, providing effective therapeutic drugs to improve the long-term prognosis of chronic heart failure. The study was rated “2023“Top Ten Highlights in the Field of Cardiovascular Disease in China of the Year” has had a major international impact and has been reported by media at home and abroad.

　　nation973Evaluation of the Plan Acceptance Expert Group: This study created“theory+clinical+new medicine+experiment+A new model of academic innovation and transformation of traditional Chinese medicine integrated with “evidence-based”the combination of traditional Chinese medicine theoretical innovation and modern science and technology has produced major original results and set an example for the inheritance and innovative development of traditional Chinese medicine.

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