Lianhua Qingwen’s theoretical basis and scientific research evidence for the treatment of new crowns

[ad_1]

Plague is the collective name of traditional Chinese medicine for acute infectious diseases that are highly contagious and can cause epidemics. The “Huangdi Neijing” more than 2,000 years ago called it the “five epidemics”. In the Ming Dynasty, Wu Youke summarized the cause of the disease in his “Warm and Epidemic Theory” as feeling a kind of strange gas unique to the heaven and earth, also known as plague gas, miscellaneous gas, and hostile gas. Although the expressions are not the same, doctors of all dynasties agreed that this type of disease has the pathogenic characteristics of strong infectivity, acute onset, rapid transmission, similar symptoms, and frequent critical deaths.

“Mr. Wu Youke’s Theory of Plague”

　　Theoretical Basis of Treating Plague with Tongzhi Recipe

Diagnosis and treatment of traditional Chinese medicine begins with “disease differentiation”, and the “Fifty-two Disease Prescriptions” written in the Western Han Dynasty is the earliest medical prescription book that embodies the idea of ​​”disease differentiation and treatment”. “Huangdi Neijing” established the TCM syndrome differentiation system, and it is also the origin of TCM theory of “disease differentiation and treatment”. The syndrome differentiation of six meridians and the diagnosis and treatment model of miscellaneous diseases in Zhang Zhongjing’s “Treatise on Febrile and Miscellaneous Diseases” laid the ideological foundation for the combination of disease differentiation and syndrome differentiation in traditional Chinese medicine. The characteristic of “syndrome differentiation and treatment” in ancient Chinese medicine is that the disease is the key link and the syndrome is the goal. When the west wind spread to the east and Huitong sent physicians to create the idea of ​​integrated traditional Chinese and western medicine diagnosis and treatment, with the continuous development of science and technology, modern Chinese medicine clinical application of western medicine disease diagnosis combined with traditional Chinese medicine syndrome differentiation and treatment model gradually formed. This kind of diagnosis and treatment model seems to take the advantages of both Chinese and Western medicine, but it ignores the in-depth discussion and research application of the connotation of “disease differentiation and treatment” that already exists in Chinese medicine itself.

Mawangdui Han Tomb Silk Book “Fifty-two Disease Prescriptions”

Illness refers to the comprehensive analysis and identification of symptoms, signs, etiology, nature, location and constitution of patients under the guidance of the theory of traditional Chinese medicine, and then to make a diagnosis of the type of disease. It is the understanding of the essence of disease in traditional Chinese medicine. Syndrome is a generalization of a certain stage or a certain type of pathology in the course of a disease. It generally consists of a group of relatively fixed, internally related symptoms and signs that can reveal the essence of a certain stage of the disease or a certain type of lesion. Due to the nature of the disease, it is impossible to grasp the overall lesion law of the disease. Because of this, the prevention and treatment of plague must be combined with disease differentiation and syndrome differentiation. Treatment based on disease differentiation is the main mode. On the premise that the etiology, pathology, and disease location are very clear, it is more guaranteed to use specific diseases and specific prescriptions to clarify the curative effect ; Syndrome differentiation and treatment is a necessary supplement.

“Tongzhi Prescription” is the basic way to realize disease differentiation and treatment. Through disease differentiation and treatment, we can grasp the etiology, pathogenesis and pathogenic characteristics of the plague, and formulate prescriptions according to the key etiology and pathogenesis for the core diseases and syndromes of the plague, instead of Confined to scattered symptoms, this kind of targeted and targeted medication not only avoids the deviation of the focus of prevention and treatment, but also can effectively cut off the disease, prevent transmission, protect susceptible groups, and quickly cover a large number of patients in a short period of time. crowd. It is also because of this that “Tongzhi Fang” has been used since ancient times for a large number of patients with “similar symptoms” to effectively improve symptoms and prevent disease progression. For a small number of people with weak bodies and serious illnesses, additions and subtractions can be made on the basis of “Tongzhi Fang” combined with syndrome differentiation and treatment to deal with complex and changeable illnesses due to individual differences.

At the beginning of the plague, the early application of the effective Tongzhi formula to fight the epidemic has always been the best choice in all dynasties. Li Dongyuan, one of the four masters of the Jin and Yuan Dynasties, created Puji Xiaoxiao Decoction to treat Datouwen, which is known as “Xianfang” by the world. Zhu Danxi, one of the four masters of the Jin and Yuan Dynasties, created the “Renzhonghuang Pill” to treat plague. Wu Youke, a master of plague in the Ming Dynasty, created strange recipes such as Dayuanyin, which made countless people alive. Yun Tieqiao, a modern Chinese medicine scientist, used Maxing Shigan Decoction to treat scarlet fever, Guo Keming used Baihu Decoction to treat Japanese encephalitis, and traditional Chinese medicine to treat SARS, influenza, and new crown infection. successful example. The use of “Tongzhi Fang” to prevent and control plague embodies the characteristics of “diagnosis of disease first, supplemented by syndrome differentiation”.

　　Evidence of Lianhua Qingwen Group’s Prescriptions for the Treatment of New Crown Infection

The plague poison enters through the mouth and nose, the lungs are the main place to receive the evil, and the large intestine is its way out. The lung and the large intestine are on the outside and inside, and the disorder of lung qi circulation and the obstruction of qi in the large intestine worsen each other. Actively using the lower method can help the lung qi flow and descend, and prevent the disease from spreading and aggravating. The lung governs the opening and closing of the skin and hair, and the normal circulation of lung qi can also promote the excretion of epidemic toxins from the pores of the skin.

“Warm and Epidemic Theory” not only first recognized that the plague was caused by plague qi, but also firstly clarified the principles of chasing away evil spirits early, attacking acute syndromes urgently, using medicines in advance of syndromes, cutting off the disease, regulating the interior and exterior, and nourishing yin after the epidemic. The most prominent manifestation is that Wu Youke made good use of rhubarb in treating the plague, emphasizing that the use of “down method” does not have to be limited to the accumulation of feces and dry excrement. The method of defecating is actually a method to open the door and eliminate thieves. It is a means, and expelling evil is the goal.

For the new crown infection, although the virus strains are often mutated, and some infected people also have special symptoms such as loss of smell or taste, the main symptoms are basically similar. Patients with new crown infection often show respiratory symptoms such as fever, fatigue, body aches, cough, and expectoration, and may be accompanied by gastrointestinal symptoms such as vomiting, nausea, poor stool, anorexia, and abdominal distension. The evidence is in line with the characteristics of epidemic evil in “Warm and Epidemic Theory”.

For symptoms such as high fever, shortness of breath, and wheezing caused by the new crown infection, it is suitable to use Maxing Shigan Decoction and Yinqiao Powder to vent out with pungent coolness, clear the lungs and relieve asthma, so that the epidemic poison can be relieved from the body and qi. If the epidemic poison spreads, high fever, cough, wheezing, expectoration, abdominal distension and constipation, etc. appear in the heat, lung qi stagnation, and internal qi blockage, it is suitable to use rhubarb to expel heat, so that the evil qi will come out with the stool. Realize the purpose of dredging the lungs and purging the lungs, clearing the intestines and calming the lungs.

Lianhua Qingwen prescription, one of the “three medicines and three prescriptions” clinically used during the epidemic, is based on the addition and subtraction of Maxing Shigan Decoction and Yinqiao Powder. Medication cuts off the true meaning of the disease. The Huoxiang in its formula can aromatize dampness and protect the spleen and stomach. It can not only relieve stomach discomfort caused by bitter cold medicine, but also is suitable for the dampness syndrome shown in the new crown infection. And Yinqiaosan also has the effect of pungent coolness to save yin. The rhodiola in the prescription can benefit qi, activate blood and unblock the meridians, which can “cure severe fever, restless body heat, and evil qi”, clear away blood stasis, and modern research has proved that it can improve human immune function and hypoxia resistance, and protect pulmonary microvascular endothelial cells 1. Inhibit pulmonary fibrosis, which is just suitable for pathological changes such as chest tightness, shortness of breath, and lung tissue damage in patients with new crown infection. Wu Youke also discussed the concern that bitter and cold medicines often hurt the spleen and stomach. After taking the medicine, you can drink ginger soup or hot gruel to regulate stomach qi. Bitter and cold medicines are helpful to expel evil heat and plague quickly, so they are indispensable. Modern research also shows that heat-clearing and detoxifying medicines such as honeysuckle, forsythia, rhubarb, and Radix Radix have antibacterial and antiviral effects.

The basic and clinical research of Lianhua Qingwen has also confirmed the effectiveness of Lianhua Qingwen’s formula against new crown infection. The basic research article “Lianhua Qingwen has antiviral and anti-inflammatory effects on the new coronavirus” published in Pharmacological Research (“Pharmacological Research”) confirmed that Lianhua Qingwen can inhibit the replication of the new coronavirus in cells and reduce intracellular Virus particles reduce cell damage. Moreover, multiple network pharmacology studies have shown that Lianhua Qingwen has a broad material basis and the advantages of multi-target effects in the treatment of new crown infection. The clinical research article “Evaluation of Clinical Efficacy and Safety of Traditional Chinese Medicine Lianhua Qingwen Capsules in Patients with Novel Coronavirus Pneumonia: A Prospective, Randomized Controlled, Multicenter Clinical Trial” published in Phytomedicine (“Plant Medicine”) confirmed that, Lianhua Qingwen can improve the disappearance rate of fever, fatigue, and cough symptoms in patients diagnosed with new crown infection, shorten the duration of symptoms, improve the proportion of lung CT improvement and clinical treatment effect, and reduce the proportion of serious illness. The clinical research article “Study on the Effectiveness and Safety of Lianhua Qingwen Capsules in Preventing Novel Coronavirus Pneumonia: A Prospective Open-Label Controlled Trial” published in Evidence-Based Complementary and Alternative Medicine (“Evidence-Based Complementary and Alternative Medicine”) showed , Lianhua Qingwen can reduce the positive rate of nucleic acid in people who are in close contact with the new crown.

[ad_2]

Source link