[Stem Cell Regenerative Medicine Topic]Exclusive Interview: Liu Xiaolan, Doctor of Stem Cell Medicine from Japan

Report: aNGie Photo: Provided by the interviewee

(Kuala Lumpur) Since ancient times, people have tried their best to prolong their lifespan, hoping to live longer. However, if there is no health, no matter how long life is, it is in vain, right? Therefore, the most appropriate method is how to prolong the “healthy” life span.

Since everyone cannot escape the law of life, old age, sickness and death, how to delay aging and prevent illness is the most important thing. Therefore, the subject of “regenerative medicine” has been derived now, in order to live a life of “not getting old, not getting sick, and being healthy and long”.

The biggest key to regenerative medicine is “stem cells”. However, many people have misconceptions about stem cells, thinking that it is only a holy product for beauty lovers, aiming to restore youthful appearance. At the same time, many people question the source of stem cells, and even think that it involves ethical and moral issues.

In fact, stem cells have been widely used in medical research and development in the world, and it has been proved that it is effective for many serious and intractable diseases, such as immune-related diseases, central nervous system diseases, metabolic disorders, and circulatory system diseases. While treating these diseases, you can also get the side effects of rejuvenation and beauty!

Japanese people pay attention to “preventive medicine”

If we talk about one of the authoritative developers of stem cell therapy, Liu Xiaolan, a doctor of stem cell medicine from Japan who is a national treasure in China, is the executive director of the International Society of Anti-Aging Medicine and the executive director of Sun Field Clinic.

The 66-year-old Dr. Liu Xiaolan has smooth and fair skin like a baby, because she uses stem cells and supernatant as regular health care.

As early as more than 30 years ago, Liu Xiaolan was a specialist in endocrine and metabolic diseases at Beijing Children’s Hospital in China. Later, due to national medical and cultural exchanges, she was sent to Japan Medical University to do research and study for a doctor of medicine there. She has stayed in Japan ever since.

She said that at that time, the Japanese people had already paid great attention to “preventive medicine”, even if they were not sick, they would do health management. The Japanese are generally aware of health care products, and believe that it is very important to use health care products to maintain their health and prevent them from getting sick. Therefore, medical research also focuses on how to keep people from getting sick and making them healthier.

Over the years, the research on disease prevention and anti-aging has achieved rapid development, because after anti-aging, organs become younger and diseases can be prevented at the same time.

At that time, the term “regenerative medicine” did not yet exist, but research on similar concepts existed in the 1950s and 1960s, and it became more vigorous in the 1980s and 1990s. Liu Xiaolan conducted basic animal experiments in Japan in the 1990s, including treating liver cirrhosis and acute pneumonia with stem cell factors. Fifteen years later, he began to engage in research on the clinical application of stem cells in the human body.

She said: “The research on stem cell regenerative medicine has been carried out for many years, and now the whole world is focusing on the study of the effectiveness and safety of stem cells. In fact, as long as it is a real stem cell, it must be effective, but how to ensure its safety. Stem cell therapy is not allowed in many countries, mainly due to market regulation issues, if there is no standard, it is easy to go wrong.”

Along with the research and development of regenerative medicine, Dr. Liu Xiaolan joined Sun Field Clinic, which was established in 2008, to carry out stem cell regenerative medicine together with a group of stem cell medical doctors and medical teams. At the same time, it also jointly develops related regenerative medical technology with Japan’s most authoritative Rohto Group.

Stem cells decrease with age

In 2009, Liu Xiaolan participated in the founding of the International Society of Anti-aging and Regenerative Medicine in Japan, which is mainly used as a platform for the exchange of medical technology and health management products. The purpose is how to make people not old and sick, prevent and treat diseases while anti-aging. As the executive director, Liu Xiaolan pointed out that to achieve the above goals, regenerative medicine is one of the important means, which mainly includes the research of anti-aging medicine, preventive medicine and clinical treatment medicine.

After more than 10 years of stem cell clinical treatment, the Sun Field Clinic she served has also obtained two clinical treatment qualifications issued by the Ministry of Health, Labor and Welfare of Japan, namely the prevention of arteriosclerosis in 2016 and the alleviation of chronic pain in 2017. In addition, the clinic’s years of research results have been summarized into papers, and the papers on the prevention and treatment of arteriosclerosis and anti-aging effects of stem cells will be published in the world-renowned magazine “Stem Cell Research & Therapy” in the field of regenerative medicine in 2020, and in 2022 in Europe. The famous journal “European Review for Medical and Pharmacological Sciences” published a paper on the effect of stem cell supernatant in the treatment of chronic pain.

What exactly are stem cells? Stem cells are the most primitive cells, capable of forming specific tissue differentiation and organ development. Functions that have been identified include the ability to renew, repair, meristem, and differentiate tissues, among others.

Liu Xiaolan pointed out that the main function of stem cells in the human body is to repair bad cells, but it will decrease with age. Stem cells are used for repair and treatment. And the most important thing is preventive treatment to prevent the disease from happening.

Although stem cells are being researched all over the world, many governments do not approve the treatment certification, and Japan is one of the countries where the government has licensed stem cell therapy.

“Currently approved in Japan are ES or iPS cells for research, autologous mesenchymal stem cells for clinical treatment, and immune cell therapy for cancer patients.

Mesenchymal stem cells from bone marrow fat

There are currently three types of stem cells that are more common, namely embryonic stem cells (ES cells), iPS artificial cells and mesenchymal stem cells.

In contrast, embryonic stem cells are derived from the cell mass in the blastocyst. Although they have the ability to proliferate and differentiate, they do not exist in the human body, are carcinogenic, and have moral controversy (because of the use of fertilized eggs).

iPS cells are artificial stem cells, which do not exist in the human body. They are derived from differentiated cells in the body. They have the ability to proliferate and differentiate, but they are easy to transform into tumors.

Mesenchymal stem cells, also known as adult stem cells, are derived from bone marrow, fat, and umbilical cord. They have the ability to proliferate, but their differentiation potential is limited and they are not carcinogenic.

“Since 2015, the Japanese government has stipulated that only autologous mesenchymal stem cells (Mesenchymal Stem Cell) can be used clinically as a treatment, and can only be used on individuals. Although the sources of mesenchymal stem cells include bone marrow, fat and umbilical cord, but The source of fat is relatively simple and easy to obtain, so fat stem cells are generally used as the main source.”

Are there differences in stem cells taken from different age groups and from different sites? She said that stem cells have nothing to do with age group, the effect of culture depends on whether the activity is good or not. As for stem cells from different sources, it depends on various factors, including the culture medium and culture technology, which will cause their effectiveness, ineffectiveness and safety.

adipose tissue culture

infusion of stem cells into the body

What is stem cell therapy? Dr. Liu Xiaolan revealed: Generally, the subcutaneous fat tissue (10 to 20 grams) is taken from the recipient (both sides of the navel), and then the fat is quickly sent to the culture center, and pure mesenchymal stem cells are isolated from the fat tissue, and then cultured. Let the stem cells divide, and after 6 to 8 weeks, the successfully cultivated stem cells will be infused into the body of the healer through veins.

“Before that, we will tell each other about the stem cell treatment, and we will also pass an infection test first. If everything is negative, we can proceed.”

Regenerate damaged cells for the better

These stem cells are infused back into the body, which has a function called “homing”, that is, when there is a problem with certain tissues in the body, a signal is sent when cells are damaged, and those stem cells will pass through the lymph and Peripheral blood, on its own, finds the problematic part and repairs it, allowing damaged cells to “regenerate”. That is, a good cell and a bad cell are fused together, and finally two good cells will be formed.

When the bad cells in the tissue become good and have the ability to regenerate, it is conceivable that the part will gradually recover, and the appearance will also be greatly improved, and the mental strength and immunity will also be improved.

“Of course, it doesn’t mean that after stem cell treatment, you will live forever. The body will still degenerate with age, but it will be younger, healthier and more energetic than your peers, and aging will be slower. Therefore, it is recommended to do it early, so that the treatment effect can be maintained. longer.”

Of course, stem cell therapy also has risks. If the stem cells injected into the human body are truly effective and active, there will be no problem in terms of safety. But if the infusion is very low survival rate or even dead stem cells, it can lead to the death of the patient from pulmonary embolism!

Japan sets a limit of 200 million

“So before importing, we must ensure that the stem cells are active. In addition to confirming the survival rate, we must also confirm the quantity. If the quantity is too large, it will also cause pulmonary embolism in the patient. The upper limit of the quantity stipulated in Japan is 200 million, that is, One reinfusion can be up to 200 million yuan, if too much, you will die from pulmonary embolism.”

“The low cell survival rate and death before input are all related to whether the culture medium and related technologies are good, so supervision is very important. For example, in addition to our rich experience and technology, the culture medium used is also completely free of animal origin (AOF), so it is very important. Safety.”

Stem cells for the new normal after the epidemic

Anti-disease and anti-aging beauty

Before the COVID-19 epidemic, people’s impression of stem cell therapy was limited to beauty and anti-aging, but in fact, people with money have always chosen to undergo this treatment, most of which are to prevent arteriosclerosis and other diseases. Health care is the goal, and beauty is only a subsidiary effect obtained from a healthy body.

Liu Xiaolan revealed that since the COVID-19 epidemic, more and more people choose stem cell therapy for health care and disease prevention. After all, stem cells have innumerable functions.

In addition to repairing, it can also relieve pain and reduce inflammation

“The clinical treatment we have done in Japan includes the repair of the nervous system, liver cirrhosis, kidney disease, heart failure, and repair of accidental injuries. In addition, there are also some difficult and miscellaneous diseases such as brain diseases, Parkinson’s disease, etc., can be improved.”

“In addition to repairing, the strength of stem cells can also relieve pain, reduce inflammation, and regulate the balance of the body, so many diseases have been improved. For example, liver cirrhosis, which cannot be reversed in traditional medicine, just try to maintain it and slow down the deterioration. But stem cells But it has the function of repairing and restoring the liver back to normal. In addition, patients also get unexpected benefits after treatment, such as enhanced mental and physical strength, hair growth, less chance of catching colds, and improved immunity.”

It is reported that mesenchymal stem cells have been proven to be helpful for the following diseases:

1. Immune-related diseases

Rheumatoid arthritis, atopic dermatitis, inflammatory bowel disease, immunosuppression, multiple sclerosis, lupus erythematosus, etc.

2. Central nervous system diseases

Alzheimer’s disease (dementia), amyotrophic lateral sclerosis, Parkinson’s disease, spinal cord injury, etc.

3. Metabolic disorders

Type 1 diabetes, type 2 diabetes.

4. Circulatory system diseases

Brain disease, heart failure, limb ischemia, liver disease, etc.

Supernatant improves skin anti-aging

She pointed out that in fact, when cultivating stem cells, there is an accompanying product “supernatant”, which also has a great effect on improving skin, anti-aging and body functions.

“This is the nutrient solution for stem cells. During the culture of stem cells, many physiologically active substances will be secreted. These cytokines include growth factors, anti-inflammatory factors, nerve regeneration factors, etc. After the stem cells are cultured in the culture medium and taken out, The remaining liquid (the supernatant) contains hundreds of factors, each of which has a function to repair aging damaged cells and promote tissue regeneration.”

“If you want to make a comparison, if you want to remove wrinkles, many people will inject hyaluronic acid. After the injection, it will be absorbed slowly. The short-term effect can only last 3 to 6 months, and the long-term effect is only 2 years. After the absorption, it will return to the original state. Condition, because it is just a filling, without any regenerative function; the supernatant is different, although it is also a filling function at the beginning, but it will get better and better later, because there are regenerative factors in it, which can not only maintain, but also continue to regenerate Improve, so that users have the effect of rejuvenation.”

Joint Injections Improve Joint Pain

Stem cell supernatant has also received attention in clinical practice as a kind of regenerative medicine. It is reported that injecting it in different parts will achieve different effects:

Intravenous injection: General state improvement

Face Injection: Improves Wrinkles and Sagging Skin

Head Injection: Improves Hair Thinning and Hair Loss

Joint injections: Improve joint pain (knee, shoulder)

Clinical treatment progress case sharing

Stem cells have also helped various patients in clinical treatment. Dr. Liu cited the following examples;

1. A 57-year-old polio patient, who was completely immobile in his left leg, regained motor function in his left leg when he was treated with a dry bag for more than a year.

2. A man with chronic obstructive pneumonia, he can only lie in bed all day long, because he can’t breathe, and he has to rely on oxygen to maintain his life. If this is based on traditional treatment, it can only inhibit the progress and not reverse it. One and a half years after he received the stem cell treatment, his originally fibrotic lung (white lung) recovered and he could move around like a normal person.

3. A 52-year-old man with Parkinson’s disease, his hands and feet trembled uncontrollably, his left foot trembled so much that he couldn’t even put on his shoes, and it was even more difficult to walk. After one and a half years of treatment, his symptoms have greatly improved and he can take care of himself.

4. Not only humans, stem cell therapy is also effective for dogs. One puppy was unable to walk due to nerve damage in its hind legs, so it could only drag itself on the ground. When he was injected with stem cells, the nerves in his legs recovered and he was able to walk normally after a month.

Extraordinary achievements in research and development

Promote to benefit the world

Dr. Liu Xiaolan has made extraordinary achievements in the research and development of stem cells, and has also won numerous awards, including the Special Lecture Award of the Japanese Interface Society, the Excellence Award of the International Exchange Center, the Fund Award for Overseas Students from the Ministry of Education of China, and 70 Chinese role models at home and abroad in the 70th anniversary of the founding of the People’s Republic of China Award, China International Economic and Technological Cooperation Forum “Chinese Star”, etc.

The 66-year-old Dr. Liu Xiaolan has smooth and fair skin like a baby, because she uses stem cells and supernatant as regular health care.

Host 5 sharing sessions in 3 days

Now she also intends to bring information about stem cell therapy and regenerative medicine to the world to benefit people.

A few days ago, under the arrangement of Albert Leong, the founder of the general agent in Southeast Asia, she came to Malaysia for 3 days and hosted 5 sharing sessions to promote the concept of how to maintain a healthy lifespan to Malaysians.

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